Creating innovative science for resolution of inflammation: Resilience and entropy of inflamed tissue. -Grant-in-Aid for Transformative Research Areas(B)

JA

Creating innovative science for resolution of inflammation:
resilience and entropy of inflamed tissue.

In this research area, we will revisit the pathogenesis of chronic inflammation from our distinctive perspective: “inflammatory tissue resilience”, “pathological inflammatory memory” and “tissue damage entropy”. By drawing a comprehensive picture of the machinery of tissue resilience governed by interactions between nerves, epithelia, stromal and immune cells, we aim to create a new discipline related to the resolution of inflammation.

Creating innovative science for resolution of inflammation:
resilience and entropy of inflamed tissue.

In this research area, we will revisit the pathogenesis of chronic inflammation from our distinctive perspective: “inflammatory tissue resilience”, “pathological inflammatory memory” and “tissue damage entropy”. By drawing a comprehensive picture of the machinery of tissue resilience governed by interactions between nerves, epithelia, stromal and immune cells, we aim to create a new discipline related to the resolution of inflammation.

Purpose of the Research Project

NEWS

Publication2022/10/21
“Interleukin-33-activated neuropeptide CGRP-producing memory Th2 cells cooperate with somatosensory neurons to induce conjunctival itch” (A01: Team Hirahara)
Publication2022/10/05
“Enrichment of type I interferon signaling in colonic group 2 innate lymphoid cells in experimental colitis” (C01: Team Mikami)
NEWS2022/04/01
Dr. Kiyoshi Hirahara (A01) to become Full Professor, Department of Immunology, Chiba University.
Publication2022/03/08
“Nematode ascarosides attenuate mammalian type 2 inflammatory responses” (A01: Team Hirahara)
NEWS2022/01/11
Website released.

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