Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo
The aim of this study (B01) is to identify a subset of macrophages common to multiple organs, that emerges during resolution of inflammation (whether due to injury or infection) and is involved in the restoration of inflamed tissues. We will clarify the roles of these “restorative macrophages” and their associated protein AIM (a secreted scavenger protein produced by this population) in the inflammatory tissue resilience, and investigate their functional changes with aging, which will lead to approaches for future clinical applications.
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Grant-in-Aid for Transformative
, "Resolution of Inflammation". All Right Reserved.
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