Creating innovative science for resolution of inflammation: Resilience and entropy of inflamed tissue. -Grant-in-Aid for Transformative Research Areas(B)

C01 : Yohei MIKAMI

C01 : Yohei MIKAMI

C01 Yohei MIKAMI


Keio University School of Medicine
Associate Professor

Reserch contents

Gastrointestinal fibrosis is a state of accumulated biological entropy caused by a dysregulated tissue repair response. Acute or chronic inflammation in the gastrointestinal tract, including inflammatory bowel disease, particularly Crohn’s disease, induces fibrosis and strictures, which often require surgical or endoscopic intervention. Compared to recent progress in controlling inflammation, our understanding of the pathogenesis of gastrointestinal fibrosis is limited, which requires the development of prevention and treatment strategies.

In this research proposal, we focus on gastrointestinal fibrosis in IBD, and aim to elucidate how tissue damage entropy is increased by the acquisition of tissue resident cell diversity. The goal of our research project supported by “Grant-in-Aid for Transformative Research Areas” is set to identify the specific cell populations responsible for increasing tissue damage entropy using a comprehensive gene expression analysis of various cell populations, including the resident stromal cells. This will allow us to gain a global picture underlying pathology of gut fibrosis and open a new possibility to develop new therapeutic strategies to treat fibrostenotic diseases of the digestive system.