Creating innovative science for resolution of inflammation: Resilience and entropy of inflamed tissue. -Grant-in-Aid for Transformative Research Areas(B)

A01 Kiyoshi HIRAHARA

Reserch contents

The aim of our study (A01) is to elucidate the cellular- and molecular-mechanisms of induction and maintenance of “inflammatory memory” during the resolution of inflammation.  Especially, my team will elucidate the molecular mechanisms by which tissue-resident memory CD4⁺ T cells differentiate and persist over a long time in the inflamed tissues.  We will also focus on the acquired immunity-dependent peripheral nerve elongation in the inflamed tissues to understand the tissue damage entropy induced by the neuro-immune correlation.  Furthermore, we will conduct Proof of Concepts (POCs) using human samples.

• ORCID：https://orcid.org/0000-0002-9128-9449
• MyBibliography：https://www.ncbi.nlm.nih.gov/myncbi/kiyoshi.hirahara.1/bibliography/public/
• Resaerchmap：https://researchmap.jp/Immun5455?lang=en
• Lab：https://www.m.chiba-u.ac.jp/class/meneki/english/index.html

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